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WM-1119

WM-1119

Item no.	V3686-10mg
Manufacturer	InvivoChem LLC
CASRN	2055397-28-7
Amount	10 mg
Quantity options	100 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3686CAS #:2055397-28-7Purity >=98% Description: WM-1119 is a novel, highly potent, and selective inhibitor of KAT6A/B (lysine acetyltransferase) with an IC50 value of of 0.25 uM for KAT6A, KD value of 2 nM for KAT6A, KD value of 2.2 uM for KAT5, and KD value of 0.5 uM for KAT7. WM-1119 induces cell cycle exit and cellular senescence without causing DNA damage. Senescence is INK4A/ARF-dependent and is accompanied by changes in gene expression that are typical of loss of KAT6A function. WM-1119, which has increased bioavailability, arrests the progression of lymphoma in mice. We anticipate that this class of inhibitors will help to accelerate the development of therapeutics that target gene transcription regulated by histone acetylation. References: Nature. 2018 Aug; 560(7717):253-257.
Molecular Weight (MW)	389.38
Formula	C??H??F?N?O?S
CAS No.	2055397-28-7
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: >= 150 mg/mL (385 mM)
	Water:
	Ethanol:
Synonyms	WM-1119; WM 1119; WM1119

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 mg

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Delivery expected until 11/6/2025

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