ADH-503 [(Z)-Leukadherin-1 choline]

Description: ADH-503 (Z)-Leukadherin-1 choline is a novel, potent, selective, orally bioactive and allosteric agonist of the integrin CD11b to mitigate myeloid cell immunosuppression. The partial activation of CD11b by ADH-503 leads to the repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhanced dendritic cell responses. These actions, in turn, improve antitumor T cell immunity and render checkpoint inhibitors effective in previously unresponsive PDAC models.

References: Agonismof CD11b reprograms innate immunity to sensitize pancreatic cancer toimmunotherapies. Sci Transl Med. 2019 Jul 3; 11(499).

Related CAS #: 2055362-74-6 (choline) 2055362-72-4 (free base)