SRT3109

Description: SRT3109 is a novel and potent antagonist of CXCR2 (C-X-C chemokine receptor type 2) with a pIC50 of 8.2 and is used in the research of chemokine mediated diseases. CXCRs (CXC chemokine receptors) are integral membrane proteins that specifically bind and respond to cytokines of the CXC chemokine family. They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins, since they span thecell membrane seven times. There are currently seven known CXC chemokine receptors in mammals, named CXCR1 through CXCR7. CXCR1 and CXCR2 are closely related receptors that recognize CXC chemokines that possess an E-L-R amino acid motif immediately adjacent to their CXC motif.

References: WO2010007427A1