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ETELCALCETIDE

ETELCALCETIDE

Item no.	V3932-25mg
Manufacturer	InvivoChem LLC
CASRN	1262780-97-1
Amount	25 mg
Quantity options	100 mg 10 mg 250 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3932CAS #:1262780-97-1 Purity >=98% Description: Etelcalcetide (formerly known as AMG 416, KAI-4169 and velcalcetide, trade name Parsabiv) is an FDA approved calcimimetic drug for the treatment of secondary hyperparathyroidism in patients undergoing hemodialysis. It is administered intravenously at the end of each dialysis session. Etelcalcetide functions by binding to and activating the calcium-sensing receptor in the parathyroid gland. Parsabiv is currently owned by Amgen and Ono Pharmaceuticals in Japan. Etelcalcetide is a peptide consisting mostly of D-amino acids instead of the common L-amino acids. More specifically, it is the disulfide of N-acetyl-D-cysteinyl-D-alanyl-D-arginyl-D-arginyl-D-arginyl-D-alanyl-D-argininamide with L-cysteine. References: Nephrology Dialysis Transplantation. 2014, 29 (2): 385–92. Related CAS#:1334237-71-6 (HCl)
Molecular Weight (MW)	1048.26
Formula	C38H73N21O10S2
CAS No.	1262780-97-1 (free base);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM
	Water: N/A
	Ethanol: N/A
Chemical Name	D-Argininamide, N-acetyl-D-cysteinyl-D-alanyl-D-arginyl-D-arginyl-D-arginyl-D-alanyl-, disulfide with L-cysteine
Synonyms	Velcalcetide, trade name Parsabiv; AMG-416, AMG416, AMG 416, KAI-4169, KAI 4169, KAI4169, ONO5163, ONO-5163, ONO 5163, Etelcalcetide, Velcalcetide, Telcalcetide. Ac-D-Cys-D-Ala-D-Arg-D-Arg-D-Arg-D-Ala-D-Arg-NH2
SMILES Code	C[CH](NC([CH](NC([CH](NC([CH](NC([CH](NC([CH](NC(C)=O)CSSC[CH](N)C(O)=O)=O)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)C(N[CH](C(N)=O)CCCNC(N)=N)=O

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Amount: 25 mg

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Delivery expected until 9/4/2025

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