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ETELCALCETIDE HCL

ETELCALCETIDE HCL

Item no.	V3933-50mg
Manufacturer	InvivoChem LLC
CASRN	1334237-71-6
Amount	50 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3933CAS #:1334237-71-6 Purity >=98% Description: Etelcalcetide (formerly known as AMG 416, KAI-4169 and velcalcetide, trade name Parsabiv) is an FDA approved calcimimetic drug for the treatment of secondary hyperparathyroidism in patients undergoing hemodialysis. It is administered intravenously at the end of each dialysis session. Etelcalcetide functions by binding to and activating the calcium-sensing receptor in the parathyroid gland. Parsabiv is currently owned by Amgen and Ono Pharmaceuticals in Japan. Etelcalcetide is a peptide consisting mostly of D-amino acids instead of the common L-amino acids. More specifically, it is the disulfide of N-acetyl-D-cysteinyl-D-alanyl-D-arginyl-D-arginyl-D-arginyl-D-alanyl-D-argininamide with L-cysteine. References: Nephrology Dialysis Transplantation. 2014, 29 (2): 385–92. Related CAS#:1262780-97-1 (free base)
Molecular Weight (MW)	1084.72
Formula	C38H74ClN21O10S2
CAS No.	1334237-71-6 (HCl)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM
	Water: N/A
	Ethanol: N/A
Chemical Name	D-Argininamide, N-acetyl-D-cysteinyl-D-alanyl-D-arginyl-D-arginyl-D-arginyl-D-alanyl-, disulfide with L-cysteine hydrochloride
Synonyms	Velcalcetide HCl, trade name Parsabiv; AMG-416 HCl, AMG416, AMG 416, KAI-4169, KAI 4169, KAI4169, ONO5163, ONO-5163 HCl, ONO 5163, Etelcalcetide, Velcalcetide, Telcalcetide. Ac-D-Cys-D-Ala-D-Arg-D-Arg-D-Arg-D-Ala-D-Arg-NH2 HCl
SMILES Code	C[CH](NC([CH](NC([CH](NC([CH](NC([CH](NC([CH](NC(C)=O)CSSC[CH](N)C(O)=O)=O)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)C(N[CH](C(N)=O)CCCNC(N)=N)=O.Cl

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Amount: 50 mg

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