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adu-s100

adu-s100

Item no.	V3938-5mg
Manufacturer	InvivoChem LLC
CASRN	1638241-89-0
Amount	5 mg
Quantity options	100 mg 10 mg 25 mg 2 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3938CAS #:1638241-89-0 Purity >=98% Description: ADU-S100 (formerly known as MIW815), a cyclic dinucleotide, is a novel and potent agonist of STING (Stimulator of Interferon Genes). ADU-S100 has the potential to be used in cancer immunotherapy. It elicits potent and durable anti-tumor immunity when administered intratumorally in pre-clinical syngeneic tumor models. As of 2018, it has entered phase I clinical trials for the treatment of cancer. Clinical candidate STING agonist ADU-S100 (S100) is used in an intratumoral dosing regimen optimized for adaptive immunity to uncover requirements for a T cell-driven response compatible with checkpoint inhibitors (CPIs). References: Cell Rep. 2018 Dec 11; 25(11):3074-3085.e5. Related CAS#:1638750-95-4 (sodium); 1638750-96-5 (ADU-S100 ammonium salt)
Molecular Weight (MW)	736.52
Formula	C20H24N10Na2O10P2S22
CAS No.	1638241-89-0 (free acid);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 10 mM
	Water: N/A
	Ethanol: N/A
Synonyms	ADU-S100; ADU S100; ADUS100; ML RR-S2 CDA sodium salt; ML RR S2 CDA; ML RRS2 CDA; MIW815; MIW-815; MIW 815
SMILES Code	O[CH]1[CH](O[CH]([CH]1O2)N3C4=C(N=C3)C(N)=NC=N4)CO[P](S)(O[CH]5[CH]([CH](O[CH]5CO[P]2(S)=O)N6C7=C(N=C6)C(N)=NC=N7)O)=O.[Na+].[Na+]

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Amount: 5 mg

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