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VIPADENANT

VIPADENANT

Item no.	V3943-250mg
Manufacturer	InvivoChem LLC
CASRN	442908-10-3
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3943CAS #:442908-10-3Purity >=98% Description: Vipadenant (formerly known as BIIB-014 and CEB-4520) is a novel potent, selective and orally bioaactive antagonist of adenosine A2A receptor with Kis of 1.3 nM and 68 nM for A2A and A1 respectively. Vipadenant is under investigation for for treating Parkinson's disease. Vipadenant was evaluated in phase II clinical trials. Vipadenant showed excellent binding affinity for A2A and had modest selectivity against A1 and A2B (Ki = 63 nM), while it showed good selectivity against A3 (Ki = 1005 nM). When tested in vivo in the mouse and rat haloperidol-induced hypolocomotion models, 44 had a minimum effective dose of 0.1 and 1 mg/kg, respectively. References: Brain Res Bull. 2013 Sep; 98:163-9; ACS Chem Neurosci. 2011 Oct 19; 2(10): 555–567.
Molecular Weight (MW)	321.34
Formula	C16H15N7O
CAS No.	442908-10-3
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: >= 30 mg/mL
	Water: N/A
	Ethanol: N/A
Chemical Name	3-(4-amino-3-methylbenzyl)-7-(furan-2-yl)-3H-[1, 2, 3]triazolo[4, 5-d]pyrimidin-5-amine
Synonyms	CEB-4520; CEB 4520; CEB4520; BIIB014; BIIB-014; BIIB 014; V-2006; V2006; V 2006; VER-11135; VER-A00-11; VER-A00049; VER-ADO-49
SMILES Code	NC1=NC(C2=CC=CO2)=C(N=NN3CC4=CC=C(N)C(C)=C4)C3=N1

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Amount: 250 mg

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