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LENIOLISIB PHOSPHATE

LENIOLISIB PHOSPHATE

Item no.	V3969-25mg
Manufacturer	InvivoChem LLC
CASRN	1354691-97-6
Amount	25 mg
Quantity options	100 mg 10 mg 250 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3969CAS #:1354691-97-6 Purity >=98% Description: Leniolisib phosphate (formerly known as CDZ173 phosphate) is a novel, potent and selective PI3K (phosphatidylinositol 3-kinase inhibitor) inhibitor with IC50 values of 0.244, 0.424, 2.23 and 0.011 uM for PI3Kalpha, PI3Kbeta, PI3Kgamma and PI3Kdelta, respectively. It is currently in phase II/III clinical trials for the treatment of immunodeficiency disorders. Oral leniolisib led to a dose-dependent reduction in PI3K/AKT pathway activity assessed ex vivo and improved immune dysregulation. Leniolisib was well tolerated and improved laboratory and clinical parameters in APDS, supporting the specific inhibition of PI3Kdelta as a promising new targeted therapy in APDS and other diseases characterized by overactivation of the PI3Kdelta pathway. This trial was registered at www.clinicaltrials.gov as #NCT02435173. References: Blood. 2017 Nov 23; 130(21):2307-2316. Related CAS#:1354690-24-6 (free base)
Molecular Weight (MW)	548.46
Formula	C21H28F3N6O6P
CAS No.	1354691-97-6 phosphate)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: >= 150 mg/mL
	Water: N/A
	Ethanol: >= 10 mg/mL
Chemical Name	(S)-1-(3-((6-(6-methoxy-5-(trifluoromethyl)pyridin-3-yl)-5, 6, 7, 8-tetrahydropyrido[4, 3-d]pyrimidin-4-yl)amino)pyrrolidin-1-yl)propan-1-one phosphate
Synonyms	CDZ-173; CDZ 173; CDZ173 phosphate
SMILES Code	CCC(N1C[CH](NC2=C(CN(C3=CC(C(F)(F)F)=C(OC)N=C3)CC4)C4=NC=N2)CC1)=O.O=P(O)(O)O

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Amount: 25 mg

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Delivery expected until 9/4/2025

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