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OSIMERTINIB DIMESYLATE

OSIMERTINIB DIMESYLATE

Item no.	V3976-2g
Manufacturer	InvivoChem LLC
CASRN	2070014-82-1
Amount	2 g
Quantity options	100 mg 1 g 250 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3976CAS #:2070014-82-1Purity >=98% Description: Osimertinib dimesylate (formerly known as AZD-9291 dimesylate and mereletinib dimesylate) is a novel, potent, oral bioavailable, irreversible, and mutant-selective, 3rd generation EGFR inhibitor with IC50 of 12.92, 11.44 and 493.8 nM for Exon 19 deletion EGFR, L858R/T790M EGFR, and WT EGFR in LoVo cells, respectively. It inhibits both activating and resistant EGFR mutations while sparing the normal form of EGFR that is present in normal skin and gut cells, thereby reducing the side effects encountered with currently available medicines. It was approved as a cancer treatment in 2017 by both the Food and Drug Administration and the European Commission. a novel, potent, oral bioavailable, irreversible, References: Transl Lung Cancer Res. 2014 Dec; 3(6):370-2; J Med Chem. 2014 Oct 23; 57(20):8249-67. Related CAS: 1421373-66-1 (mesylate); 1421372-66-8 (AZD9291 DA - the des acryl derivative of AZD9291); 1421373-66-1 (mesylate) 1421372-66-8 (AZD9291 DA - the des acryl derivative of AZD9291); 1421373-66-1 (mesylate)
Molecular Weight (MW)	691.82
Formula	C??H??N?O?S?
CAS No.	1421373-65-0 (free base); 1421373-66-1 (mesylate)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: < 1 mg/mL
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	1% DMSO+30% PEG 300+dd H2O: 30mg/mL
Synonyms	AZD-9291 dimesylate; AZD9291; AZD 9291; Mereletinib dimesylate; Trade name: Tagrisso

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Amount: 2 g

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