Comparison

LASMIDITAN HCl (COL144 HCl, LY573144 HCl)

Item no. V3981-50mg
Manufacturer InvivoChem LLC
CASRN 613677-28-4
Amount 50 mg
Quantity options 100 mg 10 mg 250 mg 25 mg 500 mg 5 mg
Category
Type Biochemicals
Specific against other
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Available
Description
InvivoChem Cat #:V3981CAS #:613677-28-4Purity >=98%

Description: Lasmiditan HCl (formerly COL-144 HCl, LY-573144 HCl) is a novel and selective 5-HT(1F) receptor agonist with Ki of 2.1 nM versus Ki of 1043 nM and 1357 nM at the 5-HT(1B) and 5-HT(1D) receptors, respectively. For the understanding of migraine pathophysiology, it is very important to note that a selective 5-HT(1F) receptor agonist like lasmiditan is effective in the acute treatment of migraine. Thus, migraine can be treated with a drug that has no vasoconstrictor ability. While lasmiditan most likely is effective in the treatment of migraine attacks it had, unfortunately, a high incidence of CNS related AEs in the oral RCT. If confirmed in larger studies in phase III, this might adversely limit the use of this highly specific non-vascular acute treatment of migraine. Larger studies including the parameters of patients' preferences are necessary to accurately position this new treatment principle in relation to the triptans.

References: 2010 Oct; 30(10):1159-69; 2012 Jun; 13(4):271-5.

Related CAS#: 613677-28-4 (Lasmiditan HCl); 439239-92-6 (Lasmiditan hemisuccinate); 439239-90-4 (free base); 2171471-98-8 (HCl dihydrate) 2171471-99 (HCl hydrate)


Molecular Weight (MW)
413.82
Formula
C19H18F3N3O2-HCl
CAS No.
613677-28-4 (HCl)
Storage
-20C for 3 years in powder form
-80C for 2 years in solvent
Solubility (In vitro)
DMSO: > 10mM
Water: N/A
Ethanol: N/A
Chemical Name
2, 4, 6-Trifluoro-N-(6-((1-methylpiperidine-4-yl)carbonyl)pyridin-2-yl)benzamide hydrochloride
Synonyms
LY573144 HCl; LY-573144; LY 573144; COL-144; COL144 HCl; COL 144
SMILES Code
O=C(NC1=NC(C(C2CCN(C)CC2)=O)=CC=C1)C3=C(F)C=C(F)C=C3F.[H]Cl

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 50 mg
Available: In stock
available

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