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Description: Lasmiditan HCl (formerly COL-144 HCl, LY-573144 HCl) is a novel and selective 5-HT(1F) receptor agonist with Ki of 2.1 nM versus Ki of 1043 nM and 1357 nM at the 5-HT(1B) and 5-HT(1D) receptors, respectively. For the understanding of migraine pathophysiology, it is very important to note that a selective 5-HT(1F) receptor agonist like lasmiditan is effective in the acute treatment of migraine. Thus, migraine can be treated with a drug that has no vasoconstrictor ability. While lasmiditan most likely is effective in the treatment of migraine attacks it had, unfortunately, a high incidence of CNS related AEs in the oral RCT. If confirmed in larger studies in phase III, this might adversely limit the use of this highly specific non-vascular acute treatment of migraine. Larger studies including the parameters of patients' preferences are necessary to accurately position this new treatment principle in relation to the triptans.
References: Cephalalgia. 2010 Oct; 30(10):1159-69; J Headache Pain. 2012 Jun; 13(4):271-5.
Related CAS#: 613677-28-4 (Lasmiditan HCl); 439239-92-6 (Lasmiditan hemisuccinate); 439239-90-4 (free base); 2171471-98-8 (HCl dihydrate) 2171471-99 (HCl hydrate)
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
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