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Description: AZD7986 (formerly known as INS 1007) is a novel, second generation, highly potent, reversible, and selective DPP1 (Dipeptidyl peptidase 1) inhibitor pIC50s of 6.85, 7.6, 7.7, 7.8, and 7.8 in human, mouse, rat, dog and rabbit, respectively. It is free from aorta binding liabilities found for earlier compound series and has the potential for treating COPD (chronic obstructive pulmonary disease) with predicted human PK properties suitable for once daily human dosing.
References: J Med Chem. 2016 Oct 27; 59(20):9457-9472.
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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