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ML-7 HCl

ML-7 HCl

Item no.	V4009-50mg
Manufacturer	InvivoChem LLC
CASRN	110448-33-4
Amount	50 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4009CAS #:109376-83-2 (free base)Purity >=98% Description: ML-7 hydrochloride (HCl), a novel naphthalene sulphonamide derivative, is a potent inhibitor of Myosin light chain kinase (MLCK) with IC50 of 300 nM and IC50> 10 uM for MLCK and TRPC6 channel respectively. Myosin light chain kinase (MLCK) plays a pivotal role in regulation of cellular functions, the evidence often relying on the effects of extracelluarly administered drugs such as ML-9. Here we report that this compound exerts non-specific inhibitory actions on the TRPC6 channel, a transient receptor potential (TRP) protein. Description: References: Br J Pharmacol. 2007 Sep; 152(1):122-31. References:
Molecular Weight (MW)	452.74
Formula	C15H18ClIN2O2S
CAS No.	110448-33-4
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: >= 40mg/mL
	Water: N/A
	Ethanol: N/A
Chemical Name	Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1, 4-diazepine hydrochloride
Synonyms	ML-7 HCl; ML-7 hydrochloride; ML7.
SMILES Code	O=S(N1CCNCCC1)(C2=C3C=CC=C(I)C3=CC=C2)=O.[H]Cl

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Amount: 50 mg

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