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Regorafenib D3 (BAY 73-4506 D3) is a deuterated form of Regorafenib. Regorafenib(also known as BAY 73-4506) is a multi-kinase inhibitor which targetsVEGFR1, VEGFR2, VEGFR3, PDGFRbeta, Kit, RET and Raf-1 with IC50 values of13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM in cell-free assays, respectively. It is an orally bioavailable small molecule that hasanticancer activity and has been approved by FDA for the treatment ofliver cancer. Int J Cancer, 2011, 129(1), 245-255.
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