Comparison

mmp-9-in-1-hcl

Item no. V40643-100mg
Manufacturer InvivoChem LLC
CASRN N/A
Amount 100 mg
Quantity options 250 mg 50 mg
Category
Type Biochemicals
Specific against other
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Available
Description
InvivoChem Cat #:V40643CAS #:N/APurity >=98%

Description: MMP-9-IN-1 HCl is a novel, potent and selective matrix metalloproteinase-9 (MMP-9) inhibitor that is able to inhibit tumor growth and metastasis by reducing cell migration and proliferation. It was identified from an in silico docking approach and evaluated using biochemical and biological approaches. MMP-9-IN-1 specifically binds to the PEX domain of MMP-9, but not other MMPs. This interaction between MMP-9-IN-1 and the PEX domain results in the abrogation of MMP-9 homodimerization and leads to blockage of a downstream signaling pathway required for MMP-9-mediated cell migration. In a tumor xenograft model, MMP-9-IN-1 retarded MDA-MB-435 tumor growth and inhibited lung metastasis.

References: Small-molecule anticancer compounds selectively target the hemopexin domain of matrix metalloproteinase-9. Cancer Res. 2011 Jul 15; 71(14):4977-88.

Related Cas#: 502887-71-0(free base)

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 mg
Available: In stock
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