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Description: Phthalazinone pyrazole is a novel potent inhibitor of Aurora A kinase with IC50 of 31 nM. It does not inhibit Aurora B kinase at doses up to 100 uM. Phthalazinone pyrazole inhibits the proliferation of HCT116, COLO 205, and MCF-7 cells (IC50 = 7.8, 2.9, and 1.6 uM, respectively).
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