kmup-1

Item no.	V4099-250mg
Manufacturer	InvivoChem LLC
CASRN	81996-46-5
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4099CAS #:81996-46-5Purity >=98% Description: KMUP-1, a xanthine derivative, has been demonstrated to modulate K+-channel activity in smooth muscles and is a stimulator of the NO/sGC/cGMP pathway. KMUP-1 prevents STZ impairment of MA reactivity, eNOS levels and KATP channels, and accordingly protects against vascular dysfunction in diabetic rats. . KMUP-1 significantly attenuated STZ-stimulated MA contractions in response to high K+, suggesting that KMUP-1 may partly restore the vascular reactivity of MAs. In addition, STZ decreased the expression of endothelial nitric oxide synthase (eNOS) and this effect was reversed by KMUP-1, suggesting that KMUP-1could improve STZ-induced vascular endothelial dysfunction. Description: References: Molecules. 2018 Sep 23; 23(10). pii: E2433; Pharmacol Rep. 2018 Aug; 70(4):746-752. References:
Molecular Weight (MW)	402.88
Formula	C19H23ClN6O2
CAS No.	81996-46-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM
	Water: N/A
	Ethanol: N/A
Chemical Name	1H-Purine-2, 6-dione, 7-(2-(4-(2-chlorophenyl)-1-piperazinyl)ethyl)-3, 7-dihydro-1, 3-dimethyl-
Synonyms	KMUP 1; KMUP-1; KMUP1
SMILES Code	O=C(N1C)N(C)C2=C(N(CCN3CCN(C4=CC=CC=C4Cl)CC3)C=N2)C1=O

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 250 mg

available

Delivery expected until 10/2/2025

Express Delivery: Save 16 days

Compare

Add to wishlist

Get an offer