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Anagliptin (SK-0403)

Anagliptin (SK-0403)

Item no.	V4104-25mg
Manufacturer	InvivoChem LLC
CASRN	739366-20-2
Amount	25 mg
Quantity options	100 mg 10 mg 250 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4104CAS #:739366-20-2 Purity >=98% Description: Anagliptin (formerly known as SK0403) is a novel, potent, orally bioactive, highly selective inhibitor of DPP-4 (dipeptidyl peptidase 4) with an IC50 of 3.8 nM. It is less selective against DPP-8/9 (IC50 = 68, 60 nM). Anagliptin was approved for the treatment of type 2 diabetes mellitus in Japan in 2012. In addition to glycemic control, these agents showed beneficial effects on lipid metabolism in clinical trials. Anagliptin exhibited a lipid-lowering effect in a hyperlipidemic animal model, and suggested that the downregulation of hepatic lipid synthesis was involved in the effect. Anagliptin might have beneficial effects on lipid metabolism in addition to a glucose-lowering effect. Description: References: J Diabetes Investig. 2017 Mar; 8(2):155-160; Bioorg Med Chem. 2011 Dec 1; 19(23):7221-7. References: Publications Citing Use of InvivoChem Anagliptin: ACS Omega 2021, 6, 11, 7771–7777 https://doi.org/10.1021/acsomega.1c00242
Molecular Weight (MW)	383.46
Formula	C19H25N7O2
CAS No.	739366-20-2
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: >= 30mg/mL
	Water: N/A
	Ethanol: N/A
Chemical Name	(S)-N-(2-((2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)amino)-2-methylpropyl)-2-methylpyrazolo[1, 5-a]pyrimidine-6-carboxamide
Synonyms	SK-0403; SK 0403; SK0403; Brand name: Suiny
SMILES Code	O=C(C1=CN2C(N=C1)=CC(C)=N2)NCC(C)(NCC(N3[CH](C#N)CCC3)=O)C

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Amount: 25 mg

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Delivery expected until 11/6/2025

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