Olanexidine HCl

Description: Olanexidine HCl (also known as OPB-2045 HCl) is a novel monobiguanide analog with bactericidal activity. It was approved for use in Japan on Jul 03, 2015. Olanexidine is an antiseptic/disinfectant compound with potent bactericidal activity against Gram-negative and Gram-positive bacteria, for use in preparing patients for surgery and preventing of postoperative bacterial infections. Oanexidine probably binds to the cell membrane and disrupts membrane integrity and that its bacteriostatic and bactericidal effects are caused by irreversible leakage of intracellular components. At relatively high concentrations, olanexidine aggregates cells by denaturing proteins. This mechanism differs slightly from that of a similar biguanide compound, chlorhexidine.

References: Antimicrob Agents Chemother. 2015 Aug; 59(8):4551-9.

Related CAS#:799787-53-4 (Gluconate); 146510-36-3 (free base); 218282-71-4 (HCl hydrate)