GK921

Item no.	V4158-100mg
Manufacturer	InvivoChem LLC
CASRN	1025015-40-0
Amount	100 mg
Quantity options	10 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4158CAS #:1025015-40-0Purity >=98% Description: GK921 is a novel and potent inhibitor of transglutaminase 2 (TGase) with an IC50 of 7.71 uM for human recombinant TGase 2. GK921 showed cytotoxicity to RCC (average GI50 in eight RCC cell lines: 0.905 uM). A single treatment with GK921 almost completely reduced tumor growth by stabilizing p53 in the ACHN and CAKI-1 preclinical xenograft tumor models. TGase 2 inhibitor GK921 abrogates RCC growth in xenograft tumor models, suggesting the possibility of a new therapeutic approach to RCC. Description: References: J Cancer Res Clin Oncol. 2014 May; 140(5):757-67. References:
	Name: GK921 CAS#: 1025015-40-0 Chemical Formula: C21H20N4O Exact Mass: 344.1637 Molecular Weight: 344.418 Elemental Analysis: C, 73.23; H, 5.85; N, 16.27; O, 4.65
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: GK921; GK-921; GK 921 IUPAC/Chemical Name: 3-(phenylethynyl)-2-(2-(pyrrolidin-1-yl)ethoxy)pyrido[2, 3-b]pyrazine InChi Key: MNYJJHBAEYKXEG-UHFFFAOYSA-N InChi Code: InChI=1S/C21H20N4O/c1-2-7-17(8-3-1)10-11-19-21(26-16-15-25-13-4-5-14-25)24-18-9-6-12-22-20(18)23-19/h1-3, 6-9, 12H, 4-5, 13-16H2 SMILES Code: C12=NC=CC=C1N=C(OCCN3CCCC3)C(C#CC4=CC=CC=C4)=N2

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Amount: 100 mg

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