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AZD-8529

AZD-8529

Item no.	V4247-10mg
Manufacturer	InvivoChem LLC
CASRN	1092453-15-0
Amount	10 mg
Quantity options	100 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4247CAS #:1092453-15-0 Purity >=98% Description: AZD-8529 is a novel, potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2 (group II metabotropic glutamate receptors) with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes. AZD8529 potentiated agonist-induced activation of mGluR2 in the membrane-binding assay and in primate cortex, hippocampus, and striatum. In monkeys, AZD8529 decreased nicotine self-administration at doses (.3-3 mg/kg) that did not affect food self-administration. AZD8529 also reduced nicotine priming- and cue-induced reinstatement of nicotine seeking after extinction of the drug-reinforced responding. In rats, AZD8529 decreased nicotine-induced accumbens dopamine release. Description: References: Biol Psychiatry. 2015 Oct 1; 78(7):452-62. References: Related CAS#:1314217-69-0 (mesylate); 1344999-56-9 (mesylate hydrate)
	Name: AZD-8529 free base CAS#: 1092453-15-0 (free base) Chemical Formula: C24H24F3N5O3 Exact Mass: 487.1831 Molecular Weight: 487.4832 Elemental Analysis: C, 59.13; H, 4.96; F, 11.69; N, 14.37; O, 9.85
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: AZD8529; AZD-8529; AZD 8529. IUPAC/Chemical Name: 7-methyl-5-[3-(piperazin-1-ylmethyl)-1, 2, 4-oxadiazol-5-yl]-2-[[4-(trifluoromethoxy)phenyl]methyl]-3H-isoindol-1-one InChi Key: IPCYZQQFECEHLI-UHFFFAOYSA-N InChi Code: InChI=1S/C24H24F3N5O3/c1-15-10-17(22-29-20(30-35-22)14-31-8-6-28-7-9-31)11-18-13-32(23(33)21(15)18)12-16-2-4-19(5-3-16)34-24(25, 26)27/h2-5, 10-11, 28H, 6-9, 12-14H2, 1H3 SMILES Code: O=C1N(CC2=CC=C(OC(F)(F)F)C=C2)CC3=C1C(C)=CC(C4=NC(CN5CCNCC5)=NO4)=C3

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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Amount: 10 mg

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Delivery expected until 9/4/2025

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