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azd9056

azd9056

Item no.	V4253-10mg
Manufacturer	InvivoChem LLC
CASRN	345304-65-6
Amount	10 mg
Quantity options	100 mg 250 mg 25 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4253CAS #:345304-65-6Purity >=98% Description: AZD9056 is a novel, potent, selective, orally bioavailable antagonist of P2X7 receptor which is an adenosine triphosphate (ATP)-gated cation channel expressed on a variety of cell types believed to play a role in inflammation. AZD9056 was an inhibitor of BCRP and weakly inhibited BCRP-mediated transport of methotrexate (IC(50)=92uM). Sulfasalazine inhibited methotrexate transport mediated by all transporters studied (IC(50)< 5uM). Subsequent assessment of the in vitro data using I/IC(50) ratios indicated that both AZD9056 and sulfasalazine were unlikely to cause a DDI with methotrexate in vivo. In conclusion, to support rheumatoid arthritis drug development it is proposed that regulatory in vitro studies for OAT1, OAT3 and BCRP inhibition be routinely conducted to assess the potential for a transporter-mediated DDI with methotrexate in vivo. Description: References: Eur J Pharm Sci. 2011 May 18; 43(1-2):41-9.; Int J Mol Med. 2016 Dec; 38(6):1922-1932. References: Related CAS#:345303-91-5 (HCl)
	Name: AZD-9056 CAS#: 345304-65-6 (free base) Chemical Formula: C24H35ClN2O2 Exact Mass: 418.23871 Molecular Weight: 419.0 Elemental Analysis: C, 68.80; H, 8.42; Cl, 8.46; N, 6.69; O, 7.64
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: AZD-9056; AZD 9056; AZD9056. IUPAC/Chemical Name: Benzamide, 2-chloro-5-(3-((3-hydroxypropyl)amino)propyl)-N-(tricyclo(3.3.1.13, 7)dec-1-ylmethyl)- InChi Key: HSQAARMBHJCUOK-UHFFFAOYSA-N InChi Code: InChI=1S/C24H35ClN2O2/c25-22-5-4-17(3-1-6-26-7-2-8-28)12-21(22)23(29)27-16-24-13-18-9-19(14-24)11-20(10-18)15-24/h4-5, 12, 18-20, 26, 28H, 1-3, 6-11, 13-16H2, (H, 27, 29) SMILES Code: c1cc(c(cc1CCCNCCCO)C(=O)NCC23CC4CC(C2)CC(C4)C3)Cl

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Amount: 10 mg

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