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MK-7246

MK-7246

Item no.	V4314-10mg
Manufacturer	InvivoChem LLC
CASRN	1218918-62-7
Amount	10 mg
Quantity options	100 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4314CAS #:1218918-62-7Purity >=98% Description: MK-7246 is a novel, potent and selective CRTH2 antagonist with Ki of 2.5+/-0.5 nM. MK-7246 has high affinity for the human, monkey, dog, rat, and mouse CRTH2, it interacts with CRTH2 in a reversible manner, it exhibits high selectivity over all prostanoid receptors as well as 157 other receptors and enzymes, it acts as a full antagonist on recombinant and endogenously expressed CRTH2, it demonstrates good oral bioavailability and metabolic stability in various animal species, it yields ex vivo blockade of CRTH2 on eosinophils in monkeys and sheep, and it significantly blocks antigen-induced late-phase bronchoconstriction and airway hyper-responsiveness in sheep. MK-7246 represents a potent and selective tool to further investigate the in vivo function of CRTH2. References: Mol Pharmacol. 2011 Jan; 79(1):69-76.
	Name: MK-7246 CAS#: 1218918-62-7 Chemical Formula: C21H21FN2O4S Exact Mass: 416.12061 Molecular Weight: 416.4674 Elemental Analysis: C, 60.56; H, 5.08; F, 4.56; N, 6.73; O, 15.37; S, 7.70
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: MK7246; MK 7246; MK-7246 IUPAC/Chemical Name: (R)-2-(7-((4-fluoro-N-methylphenyl)sulfonamido)-6, 7, 8, 9-tetrahydropyrido[1, 2-a]indol-10-yl)acetic acid InChi Key: JTCAGRAKUAAYDY-OAHLLOKOSA-N InChi Code: InChI=1S/C21H21FN2O4S/c1-23(29(27, 28)16-9-6-14(22)7-10-16)15-8-11-20-18(12-21(25)26)17-4-2-3-5-19(17)24(20)13-15/h2-7, 9-10, 15H, 8, 11-13H2, 1H3, (H, 25, 26)/t15-/m1/s1 SMILES Code: O=C(O)CC1=C(CC[CH](N(S(=O)(C2=CC=C(F)C=C2)=O)C)C3)N3C4=C1C=CC=C4

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Amount: 10 mg

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Delivery expected until 11/6/2025

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