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MK-0354

MK-0354

Item no.	V4315-10mg
Manufacturer	InvivoChem LLC
CASRN	851776-28-8
Amount	10 mg
Quantity options	100 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4315CAS #:851776-28-8 Purity >=98% Description: MK-0354 is a novel and potent partial agonist of GPR109a receptor for hGPR109a/ mGPR109a with EC50 of 1.65/1.08 uM, showed no activation of GPR109b. It can be potentially used for the treatment atherosclerosis. Treatment with MK-0354 for 7 days resulted in plasma FFA suppression with minimal cutaneous flushing. However, 4 weeks of treatment with MK-0354 failed to produce changes in high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, or triglycerides. References: J. Med. Chem., 2008, 51 (16); J Clin Lipidol. 2008 Oct; 2(5):375-383.
	Name: MK-0354 CAS#: 851776-28-8 Chemical Formula: C7H8N6 Exact Mass: 176.08 Molecular Weight: 176.18 Elemental Analysis: C, 47.72; H, 4.58; N, 47.70
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: MK-0354; MK0354; MK 0354 IUPAC/Chemical Name: 3-(1H-tetrazol-5-yl)-1, 4, 5, 6-tetrahydrocyclopenta[c]pyrazole InChi Key: LTQYSJKGRPGMPO-UHFFFAOYSA-N InChi Code: InChI=1S/C7H8N6/c1-2-4-5(3-1)8-9-6(4)7-10-12-13-11-7/h1-3H2, (H, 8, 9)(H, 10, 11, 12, 13) SMILES Code: C12=C(CCC2)C(C3=NN=NN3)=NN1

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 mg

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Delivery expected until 11/6/2025

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