MK-571 Sodium (L-660711)

InvivoChem Cat #:V4326CAS #:115103-85-0 Purity >=98%

Description: MK-571 sodium (L-660711) is a novel, potent, selective, orally bioactive antagonist of leukotriene D4 (LTD4) receptor with Kis of 0.22 and 2.1 nM in guinea pig and human lung membranes. MK-571 blocks the binding of LTD4, but not LTC4, to human and guinea pig lung membranes with Ki values of 0.22 nM and 2.1 nM, respectively. MK-571 attenuates kidney ischemia and reperfusion-induced airway hypersensitivity in rats. MK-571 alters bronchoalveolar lavage fluid proteome in a mouse asthma model.

References: Can J Physiol Pharmacol. 1989 Jan; 67(1):17-28.; J Clin Invest. 2011 Jul; 121(7):2888-97.

Related CAS#: 115104-28-4 (free acid); 120443-16-5 (R-enantiomer of MK-571; L-668, 019; MK 0679; MK-679; Verlukast)

-20C for 3 years in powder form

Synonym: L-660, 711 sodium; L660, 711; L 660, 711; L-660711; L660711; L 660711; MK-571; MK 571; MK571; MK-571 sodium salt;
Chemical Name: sodium (E)-3-(((3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)((3-(dimethylamino)-3-oxopropyl)thio)methyl)thio)propanoate
InChi Key: XNAYQOBPAXEYLI-AAGWESIMSA-M
InChi Code: InChI=1S/C26H27ClN2O3S2.Na/c1-29(2)24(30)12-14-33-26(34-15-13-25(31)32)20-5-3-4-18(16-20)6-10-22-11-8-19-7-9-21(27)17-23(19)28-22; /h3-11, 16-17, 26H, 12-15H2, 1-2H3, (H, 31, 32); /q; +1/p-1/b10-6+;
SMILES Code: O=C([O-])CCSC(C1=CC=CC(/C=C/C2=NC3=CC(Cl)=CC=C3C=C2)=C1)SCCC(N(C)C)=O.[Na+]