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LAROPIPRANT

LAROPIPRANT

Item no.	V4363-250mg
Manufacturer	InvivoChem LLC
CASRN	571170-77-9
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4363CAS #:571170-77-9 Purity >=98% Description: Laropiprant (aslo known as MK-0524; Cordaptive) is a novel, potent, selective DP prostaglandin D2 (PGD2) receptor (DP) receptor antagonist with Ki values of 0.57 nM and 2.95 nM for DP receptor and TP Receptor, respectively. Laropiprant was once used as a drug in combination with niacin to reduce blood cholesterol (LDL and VLDL) that is no longer sold, due to increases in side-effects with no cardiovascular benefit. On April 28, 2008, the U.S. Food and Drug Administration (FDA) issued a 'not approved' letter for Cordaptive. Tredaptive was approved by the European Medicines Agency (EMA) on July 3, 2008. On January 11, 2013, Merck & Co Inc. announced they were withdrawing the drug worldwide as a result of European regulators recommendations. References: PLoS One. 2012; 7(8):e40222; J Med Chem. 2007 Feb 22; 50(4):794-806.
	Name: Laropiprant CAS#: 571170-77-9 Chemical Formula: C21H19ClFNO4S Exact Mass: 435.0707 Molecular Weight: 435.8944 Elemental Analysis: C, 57.87; H, 4.39; Cl, 8.13; F, 4.36; N, 3.21; O, 14.68; S, 7.35
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: MK-0524; MK0524; MK 0524; Laropiprant. Trade name: Cordaptive, Tredaptive Chemical Name: ((3R)-4-(4-Chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1, 2, 3, 4-tetrahydrocyclopenta(b)indol-3-yl)acetic acid InChi Key: NXFFJDQHYLNEJK-CYBMUJFWSA-N InChi Code: InChI=1S/C21H19ClFNO4S/c1-29(27, 28)18-10-15(23)9-17-16-7-4-13(8-19(25)26)20(16)24(21(17)18)11-12-2-5-14(22)6-3-12/h2-3, 5-6, 9-10, 13H, 4, 7-8, 11H2, 1H3, (H, 25, 26)/t13-/m1/s1 SMILES Code: O=C(O)C[CH]1CCC2=C1N(CC3=CC=C(Cl)C=C3)C4=C2C=C(F)C=C4S(=O)(C)=O

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 250 mg

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Delivery expected until 11/6/2025

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