FOSAPREPITANT DIMEGLUMINE

InvivoChem Cat #:V4400CAS #:265121-04-8 Purity >=98%

Description: Fosaprepitant dimeglumine (also known as L-758298 dimeglumine; MK0517 dimeglumine) is a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting. Fosaprepitant is used as an antiemetic drug which is administered intravenously. Fosaprepitant was developed by Merck & Co. and was approved as a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment. Fosaprepitant is a weak inhibitor of CYP3A4, and aprepitant, the active moiety, is a substrate, inhibitor, and inducer of CYP3A4.

References: J Clin Oncol. 2011 Apr 10; 29(11):1495-501.; Expert Rev Anticancer Ther. 2008 Nov; 8(11):1733-42.

Related CAS#?172673-20-0 (Fosaprepitant free acid)

-20C for 3 years in powder form

Synonym: MK0517; MK 0517; MK-0517; Fosaprepitant dimeglumine; Emend; Inemend.
IUPAC/Chemical Name: (2R, 3R, 4R, 5S)-6-(methylamino)hexane-1, 2, 3, 4, 5-pentaol hemi((3-(((2R, 3S)-2-((R)-1-(3, 5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4, 5-dihydro-1H-1, 2, 4-triazol-1-yl)phosphonate)
InChi Key: VRQHBYGYXDWZDL-OOZCZQCLSA-N
InChi Code: InChI=1S/C23H22F7N4O6P.2C7H17NO5/c1-12(14-8-15(22(25, 26)27)10-16(9-14)23(28, 29)30)40-20-19(13-2-4-17(24)5-3-13)33(6-7-39-20)11-18-31-21(35)34(32-18)41(36, 37)38; 2*1-8-2-4(10)6(12)7(13)5(11)3-9/h2-5, 8-10, 12, 19-20H, 6-7, 11H2, 1H3, (H, 31, 32, 35)(H2, 36, 37, 38); 2*4-13H, 2-3H2, 1H3/t12-, 19+, 20-; 2*4-, 5+, 6+, 7+/m100/s1
SMILES Code: O=C(N1)N(P(O)(O)=O)N=C1CN2CCO[CH](O[CH](C)C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)[CH]2C4=CC=C(F)C=C4.OC[CH](O)[CH](O)[CH](O)[CH](O)CNC.OC[CH](O)[CH](O)[CH](O)[CH](O)CNC