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PF-477736 2HCl

PF-477736 2HCl

Item no.	V4423-100mg
Manufacturer	InvivoChem LLC
CASRN	1247874-19-6
Amount	100 mg
Quantity options	10 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4423CAS #:1247874-19-6 (2HCl)Purity >=98% Description: PF-477736 di-HCl (also known as PF-736 diHCl, PF-00477736) is a novel, selective, potent and ATP-competitive Chk1 inhibitor with Ki of 0.49 nM in a cell-free assay and also inhibits VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret and Yes. It shows ca.100-fold selectivity for Chk1 than Chk2. By overriding the last checkpoint defense against DNA damaging agent-induced lethal damage, chk1 inhibitor PF-477736 may potentiate the antitumor efficacy of various chemotherapeutic agents against tumor cells with intrinsic checkpoint defects. References: Mol Cancer Ther. 2008 Aug; 7(8):2394-404; Clin Cancer Res. 2009 Jul 15; 15(14):4630-40. Related CAS: 952021-60-2 (free base); 1175132-90-7 (HCl); 1071848-28-6; 952238-93-6 (xHCl); 1247874-19-6 (2HCl) 1247874-19-6 (2HCl)
Molecular Weight (MW)	492.4
Formula	C22H27Cl2N7O2
CAS No.	1247874-19-6 (2HCl)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM
	Water: N/A
	Ethanol: N/A
Solubility (In vivo)	2% DMSO+40% PEG 300: 5 mg/mL
Synonyms	PF-736 diHCl, PF-00477736 dihydrochloride; PF-00477736; PF 00477736 dihydrochloride; PF00477736; PF-477736; PF 477736; PF477736

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Amount: 100 mg

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