UAMC-3203 HCl

Description: UAMC-3203 HCl is a novel, potent, more soluble and selective Ferroptosis inhibitor with an IC50 value of 12 nM. Ferroptosis is an iron-catalyzed, nonapoptotic form of regulated necrosis that results in oxidative lipid damage in cell membranes that can be inhibited by the radical-trapping antioxidant Ferrostatin-1 (Fer-1). Novel inhibitors derived from the Fer-1 scaffold inhibited ferroptosis potently but suffered from solubility issues. No toxicity was observed in mice after daily injection of UAMC-3203 for 4 weeks. UAMC-3203 inserts rapidly in a phospholipid bilayer in silico, which aligns with the current understanding of the mechanism of action of these compounds. In conclusion, these analogues have superior properties compared to Fer-1, show in vivo efficacy, and represent novel lead compounds with therapeutic potential in relevant ferroptosis-driven disease models.

References: J Med Chem. 2018 Nov 21; 61(22):10126-10140.

Related CAS: 2271358-64-4 (free base)