PF-1022A

Description: PF-1022A is a novel and potent N-methylated cyclooctadepsipeptides (CODPs) with excellent anthelmintic properties and acts as an ionophore. PF 1022A showed strong anthelmintic activities against Ascaridia galli in chickens. PF1022A is a novel anthelmintic that binds to the latrophilin-like transmembrane receptor important for pharyngeal pumping in nematodes. Furthermore, PF1022A binds to GABA receptors, which might contribute to the anthelmintic effect. Like other cyclodepsipeptides, PF1022A acts as an ionophore. In vitro, PF1022A showed low activity on embryonation but significantly inhibited egg hatch (10 and 100 ug/ml), whereas albendazole (10 and 100 ug/ml) revealed statistically significant inhibitions of both embryonation and egg hatch. PF1022A (1-100 ug/ml) completely inhibited larval movement at most examination points.

References: J Antibiot (Tokyo). 1992 May; 45(5):692-7.; Biochem Pharmacol. 2009 Apr 15; 77(8):1437-44.