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bgb-102

bgb-102

Item no.	V4519-10mg
Manufacturer	InvivoChem LLC
CASRN	807640-87-5 (free base)
Amount	10 mg
Quantity options	100 mg 250 mg 25 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4519CAS #:807640-87-5 (free base)Purity >=98% Description: JNJ-26483327 (also known as BGB102 and BGB-102) is a novel, potent, reversible and orally bioavailable small-molecule multitargeted tyrosine kinase inhibitor against EGFR, HER2, and HER4 with IC50s of 9.6 nM, 18 nM and 40.3 nM, respectively. It has potential antineoplastic activity. JNJ-26483327 binds to and inhibits several members of the epidermal growth factor receptor (EGFR) family, including EGFR, HER2 and HER4; Src family kinases (Lyn, Yes, Fyn, Lck and Src); and vascular endothelial growth factor receptor type 3 (VEGFR3). References: PLoS Biol. 2010 Dec 21; 8(12):e1000563. Related CAS : 807640-87-5 (free base); 1021686-80-5 (2HBr)
	Name: JNJ-26483327 CAS#: 807640-87-5 (free base) Chemical Formula: C22H25BrN4O2 Exact Mass: 456.11609 Molecular Weight: 457.3635 Elemental Analysis: C, 57.77; H, 5.51; Br, 17.47; N, 12.25; O, 7.00
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: JNJ26483327; JNJ 26483327; JNJ-26483327; BGB102; BGB-102; BGB 102. IUPAC/Chemical Name: 35-bromo-17-methoxy-5-methyl-11-oxa-2, 5-diaza-1(4, 6)-quinazolina-3(1, 2)-benzenacycloundecaphane InChi Key: JXDYOSVKVSQGJM-UHFFFAOYSA-N InChi Code: InChI=1S/C22H25BrN4O2/c1-27-8-4-3-5-9-29-21-11-17-19(12-20(21)28-2)24-14-25-22(17)26-18-10-16(23)7-6-15(18)13-27/h6-7, 10-12, 14H, 3-5, 8-9, 13H2, 1-2H3, (H, 24, 25, 26) SMILES Code: CN1CCCCCOC(C(OC)=C2)=CC3=C2N=CN=C3NC4=CC(Br)=CC=C4C1

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Amount: 10 mg

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Delivery expected until 9/4/2025

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