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Ravoxertinib hydrochloride (GDC-0994; RG7842)

Ravoxertinib hydrochloride (GDC-0994; RG7842)

Item no.	V4529-500mg
Manufacturer	InvivoChem LLC
CASRN	2070009-58-2
Amount	500 mg
Quantity options	100 mg 250 mg 25 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4529CAS #:2070009-58-2Purity >=98% Description: Ravoxertinib hydrochloride (GDC-0994; RG7842) is a novel, potent, orally bioavailable extracellular signal-regulated kinase (ERK1/2) inhibitor with IC50 of 1.1 nM and 0.3 nM, respectively. It has demonstrated anticancer activity. After oral administration, GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways. This prevents ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival. Description: Ravoxertinib hydrochloride (GDC-0994; RG7842) is a novel, potent, orally bioavailable extracellular signal-regulated kinase (ERK1/2) inhibitor with IC50 of 1.1 nM and 0.3 nM, respectively. It has demonstrated anticancer activity. After oral administration, GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways. This prevents ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival. References: J Med Chem. 2016 Jun 23; 59(12):5650-60. References: J Med Chem. 2016 Jun 23; 59(12):5650-60.References Related CAS : 2070009-58-2 (HCl); 1453848-26-4 (free base)
Molecular Weight (MW)	477.32
Formula	C??H??Cl?FN?O?
CAS No.	2070009-58-2
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 100 mg/mL
	Water: N/A
	Ethanol: N/A
Solubility (In vivo)	2% DMSO+30% PEG 300+5% Tween 80+ddH2O: 30 mg/mL
Synonyms	RG 7842 HCl; GDC0994; GDC-0994; GDC 0994; RG7842; RG-7842; RG 7842

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Amount: 500 mg

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Delivery expected until 10/2/2025

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