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NVP-LCQ-195

NVP-LCQ-195

Item no.	V4538-25mg
Manufacturer	InvivoChem LLC
CASRN	902156-99-4
Amount	25 mg
Quantity options	100 mg 10 mg 250 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4538CAS #:902156-99-4Purity >=98% Description: NVP-LCQ195 (formerly also known as AT9311; AT-9311; LCQ195; LCQ-195) is a novel and potent small molecule heterocyclic inhibitor of cyclin-dependent kinases CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM. LCQ195 induced cell cycle arrest and eventual apoptotic cell death of MM cells, even at sub-umol/l concentrations, spared non-malignant cells, and overcame the protection conferred to MM cells by stroma or cytokines of the bone marrow milieu. Cell cycle regulators, such as cyclin-dependent kinases (CDKs), are appealing targets for multiple myeloma (MM) therapy given the increased proliferative rates of tumour cells in advanced versus early stages of MM. References: Br J Haematol. 2011 Feb; 152(4):420-32.
	Name: NVP-LCQ195 CAS#: 902156-99-4 Chemical Formula: C17H19Cl2N5O4S Exact Mass: 459.0535 Molecular Weight: 460.33 Elemental Analysis: C, 44.36; H, 4.16; Cl, 15.40; N, 15.21; O, 13.90; S, 6.96
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: LCQ-195; LCQ 195; LCQ195; AT9311; AT-9311; AT 9311; NVP-LCQ-195; NVP-LCQ 195; NVP-LCQ195. IUPAC/Chemical Name: 4-[(2, 6-dichlorobenzoyl)amino]-N-(1-methylsulfonylpiperidin-4-yl)-1H-pyrazole-5-carboxamide InChi Key: CCUXEBOOTMDSAM-UHFFFAOYSA-N InChi Code: InChI=1S/C17H19Cl2N5O4S/c1-29(27, 28)24-7-5-10(6-8-24)21-17(26)15-13(9-20-23-15)22-16(25)14-11(18)3-2-4-12(14)19/h2-4, 9-10H, 5-8H2, 1H3, (H, 20, 23)(H, 21, 26)(H, 22, 25) SMILES Code: O=C(C1=C(NC(C2=C(Cl)C=CC=C2Cl)=O)C=NN1)NC3CCN(S(=O)(C)=O)CC3

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Amount: 25 mg

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Delivery expected until 9/4/2025

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