« Back
Home /
gne-0946

gne-0946

Item no.	V4555-100mg
Manufacturer	InvivoChem LLC
CASRN	1677667-24-1
Amount	100 mg
Quantity options	10 mg 1 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4555CAS #:1677667-24-1Purity >=98% Description: GNE-0946 is a novel, potent and selective RORgamma( RORc) inverse agonist with an EC50 value of 4 nM in HEK-293 cells. The nuclear receptor (NR) retinoic acid receptor-related orphan receptor gamma (RORgamma, RORc, or NR1F3) is a promising target for the treatment of autoimmune diseases. RORc is a critical regulator in the production of the pro-inflammatory cytokine interleukin-17. GNE-0946 displayed > 300-fold selectivity for RORc over the other ROR family members, PPARgamma, and NRs in our cellular selectivity panel. The favorable potency, selectivity, and physiochemical properties of GNE-0946 and GNE-6468, in addition to their potent suppression of IL-17 production in human primary cells, support their use as chemical biology tools to further explore the role of RORc in human biology. References: Bioorg Med Chem Lett. 2015 Aug 1; 25(15):2907-12.
	Name: GNE-0946 CAS#: 1677667-24-1 Chemical Formula: C22H12ClF3N2O4 Exact Mass: 460.0438 Molecular Weight: 460.79 Elemental Analysis: C, 57.35; H, 2.63; Cl, 7.69; F, 12.37; N, 6.08; O, 13.89
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: GNE0946; GNE 0946; GNE-0946 IUPAC/Chemical Name: 4-[3-(2-Chloro-6-trifluoromethyl-benzoyl)-imidazo[1, 5-a]pyridin-1-yl]-2-hydroxy-benzoic acid InChi Key: UAAUZNSONHHQQI-UHFFFAOYSA-N InChi Code: InChI=1S/C22H12ClF3N2O4/c23-14-5-3-4-13(22(24, 25)26)17(14)19(30)20-27-18(15-6-1-2-9-28(15)20)11-7-8-12(21(31)32)16(29)10-11/h1-10, 29H, (H, 31, 32) SMILES Code: O=C(O)C1=CC=C(C2=C3C=CC=CN3C(C(C4=C(C(F)(F)F)C=CC=C4Cl)=O)=N2)C=C1O

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 100 mg

available

Delivery expected until 9/4/2025

Express Delivery: Save 3 days

Compare

Add to wishlist

Get an offer