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PF-06928215

PF-06928215

Item no.	V4559-10mg
Manufacturer	InvivoChem LLC
CASRN	2378173-15-8
Amount	10 mg
Quantity options	100 mg 250 mg 25 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4559CAS #:N/APurity >=98% Description: PF-06928215 is a novel, potent, high affinity and selective cGAS (cyclic GMP-AMP Synthase) inhibitor with an IC50 of 4.9 umy. PF-06928215 is a high affinity (KD = 200 nM) active site-targeting, substrate-competitive cyclic GMP-AMP synthase (cGAS) inhibitor (IC50 = 4.9 uM; in the presence of 1 mM ATP, 0.3 mM GTP, 100 nM 45-bp interferon-stimulatory dsDNA (ISD)). PF-06928215 displays no inhibitory potency against dsDNA-induced IFN-beta expression in cellular cGAS assays, most likely due to limited cell-permeability and/or high levels of cellular ATP and GTP in the reporter cells employed. References: PLoS One. 2017 Sep 21; 12(9):e0184843.
	Molecular Weight: 380.40 Formula: C??H??N?O? SMILES: OC1=CC(C2=CC=CC=C2)=NC3=C(C(N[CH]4CCCC[CH]4C(O)=O)=O)C=NN13
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	PF-06928215; PF 06928215; PF06928215

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 mg

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Delivery expected until 9/4/2025

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