NG-25

Item no.	V4602-50mg
Manufacturer	InvivoChem LLC
CASRN	1315355-93-1
Amount	50 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #: V4602CAS #:1315355-93-1Purity >=98% Description: NG25 is a novel, potent and synthesized dual TAK1 (TGFbeta-activated kinase 1) and MAP4K2 (mitogen-activated protein kinase kinase kinase kinase 2) inhibitor, with IC50s of 149 nM and 21.7 nM, respectively. TGFbeta-activated kinase-1 (TAK1) is a key intracellular molecule participating in genotoxic stresses-induced NF-kappaB activation. Targeting TAK1 as a strategy to enhance cancer treatment efficacy has been studied in several malignancies. NG25 greatly enhanced Dox treatment efficacy in a panel of breast cancer cell lines. In this pre-clinical study, NG25 partially blocked Dox-induced p38 phosphorylation and IkappaBalpha degradation and enhanced Dox-induced cytotoxic effects and apoptosis in all breast cancer cell lines tested. Taken together, we provided clear evidence that NG25 sensitizes the breast cancer cells to Dox treatment in vitro. This combination may be an effective and feasible therapeutic option maximizing Dox efficacy and meanwhile minimizing Dox side effects in treating breast cancer. References: Sci Rep. 2016 Sep 7; 6:32737; J Med Chem. 2015 Jan 8; 58(1):183-96.
	Name: NG25 CAS#: 1315355-93-1 Chemical Formula: C29H30F3N5O2 Exact Mass: 537.2352 Molecular Weight: 537.58 Elemental Analysis: C, 64.79; H, 5.63; F, 10.60; N, 13.03; O, 5.95
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: NG25; NG-25; NG 25 Chemical Name: N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2, 3-b]pyridin-4-yloxy)-benzamide InChi Key: SMPGEBOIKULBCT-UHFFFAOYSA-N InChi Code: InChI=1S/C29H30F3N5O2/c1-3-36-12-14-37(15-13-36)18-21-6-7-22(17-24(21)29(30, 31)32)35-28(38)20-5-4-19(2)26(16-20)39-25-9-11-34-27-23(25)8-10-33-27/h4-11, 16-17H, 3, 12-15, 18H2, 1-2H3, (H, 33, 34)(H, 35, 38) SMILES Code: O=C(NC1=CC=C(CN2CCN(CC)CC2)C(C(F)(F)F)=C1)C3=CC=C(C)C(OC4=C5C(NC=C5)=NC=C4)=C3

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Amount: 50 mg

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Delivery expected until 11/6/2025

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