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Description: SB-568849 is a novel and potent melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pKi of 7.7. SB-568849 possessed good receptor affinity and selectivity. This compound proved to be an antagonist with stability in vivo, an acceptable brain-blood ratio and oral bioavailability.
References: Bioorg Med Chem Lett. 2006 Sep 15; 16(18):4872-8; Bioorg Med Chem Lett. 2006 Sep 15; 16(18):4865-71.
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