« Back
Home /
L-778123 hydrochloride

L-778123 hydrochloride

Item no.	V4632-50mg
Manufacturer	InvivoChem LLC
CASRN	253863-00-2
Amount	50 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4632CAS #:253863-00-2Purity >=98% Description: L-778123 hydrochloride is a novel and potent inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination. L-778123 can completely inhibit Ki-Ras prenylation. The combination of L-778, 123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Radiosensitization of a patient-derived pancreatic cancer cell line was observed. References: Mol Cancer Ther. 2002 Jul; 1(9):747-758.; Adv Pharm Bull. 2013; 3(1):73-77. Related CAS : 253863-00-2 (HCl); 183499-57-2 (free base); 183499-56-1 (2HCl)
	Name: L-778123 hydrochloride CAS#: 253863-00-2 (HCl); 183499-57-2 (free base); 183499-56-1 (2HCl) Chemical Formula: C??H??Cl?N?O Molecular Weight: 442.34
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: L778123 HCl; L-778123; L 778123; L778, 123; L-778, 123; L 778, 123 HCl; L-778123 hydrochloride IUPAC/Chemical Name: 4-((5-((4-(3-chlorophenyl)-3-oxopiperazin-1-yl)methyl)-1H-imidazol-1-yl)methyl)benzonitrile dihydrochloride SMILES: N#CC1=CC=C(CN2C(CN3CC(N(C4=CC=CC(Cl)=C4)CC3)=O)=CN=C2)C=C1.[H]Cl

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 50 mg

available

Delivery expected until 9/4/2025

Express Delivery: Save 7 days

Compare

Add to wishlist

Get an offer