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leq-506

leq-506

Item no.	V4664-250mg
Manufacturer	InvivoChem LLC
CASRN	1204975-42-7 or 1057677-92-5
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4664CAS #:1204975-42-7 or 1057677-92-5Purity >=98% Description: LEQ-506 (also known as NVP-LEQ506) is a novel, orally bioavailable and second-generation small-molecule inhibitor of smoothened (Smo) with IC50s of 2 and 4 nM in human and mouse, respectively. LEQ-506 has potential antineoplastic activity. LEQ506 selectively binds to the Hedgehog (Hh)-ligand cell surface receptor Smo, which may result in the suppression of the Hh signaling pathway, thereby inhibiting tumor cell growth. References: ChemMedChem. 2013 Aug; 8(8):1261-5.; Pharmacol Res Perspect. 2016 Mar 4; 4(2):e00214. Related CAS: 1204975-42-7 or 1057677-92-5
	Name: LEQ-506 CAS#: 1204975-42-7 or 1057677-92-5 Chemical Formula: C25H32N6O Exact Mass: 432.26376 Molecular Weight: 432.56 Elemental Analysis: C, 69.42; H, 7.46; N, 19.43; O, 3.70
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: LEQ506; LEQ-506; LEQ 506; NVP LEQ 506; NVP-LEQ-506; NVP LEQ-506; NVPLEQ506. Chemical Name: (R)-2-(5-(4-(6-benzyl-4, 5-dimethylpyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazin-2-yl)propan-2-ol InChi Key: POERAARDVFVDLO-QGZVFWFLSA-N InChi Code: InChI=1S/C25H32N6O/c1-17-16-30(11-12-31(17)23-15-26-22(14-27-23)25(4, 5)32)24-19(3)18(2)21(28-29-24)13-20-9-7-6-8-10-20/h6-10, 14-15, 17, 32H, 11-13, 16H2, 1-5H3/t17-/m1/s1 SMILES Code: OC(C)(C)C1=NC=C(N2[CH](C)CN(C3=NN=C(CC4=CC=CC=C4)C(C)=C3C)CC2)N=C1

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Amount: 250 mg

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Delivery expected until 9/4/2025

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