gemilukast

InvivoChem Cat #:V4684CAS #:1232861-58-3 (free acid)Purity >=98%

Description: Gemilukast (formerly also known as ONO-6950) is a novel, potent and orally bioavailable dual CysLT1 and CysLT2 (cysteinyl leukotriene 1 and 2) antagonist with IC50s of 1.7, 25 nM for human CysLT1 and CysLT2, respectively.. Gemilukast exhibited potent in vivo efficacy at an oral dose of 0.1 mg/kg given 24 h before LTD4 challenge in a CysLT1-dependent guinea pig asthmatic model. In addition, gemilukast dose-dependently reduced LTC4-induced bronchoconstriction in both CysLT1- and CysLT2-dependent guinea pig asthmatic models, and it reduced antigen-induced constriction of isolated human bronchi. Gemilukast is currently being evaluated in phase II trials for the treatment of asthma.

References: J Med Chem. 2015 Aug 13; 58(15):6093-113.; Eur J Pharmacol. 2015 Oct 15; 765:242-8.

Related CAS: 232861-58-3 (free acid); 1232861-64-1 (disodium salt); 1232873-69-6 (8 hydrate and disodium)

-20C for 3 years in powder form

Synonym: ONO-6950; ONO 6950; ONO6950
IUPAC/Chemical Name: 4, 4'-(4-fluoro-7-((4-(4-(3-fluoro-2-methylphenyl)butoxy)phenyl)ethynyl)-2-methyl-1H-indole-1, 3-diyl)dibutyric acid
InChi Key: SILHYVDKGHXGBL-UHFFFAOYSA-N
InChi Code: InChI=1S/C36H37F2NO5/c1-24-27(9-5-11-31(24)37)8-3-4-23-44-29-19-15-26(16-20-29)14-17-28-18-21-32(38)35-30(10-6-12-33(40)41)25(2)39(36(28)35)22-7-13-34(42)43/h5, 9, 11, 15-16, 18-21H, 3-4, 6-8, 10, 12-13, 22-23H2, 1-2H3, (H, 40, 41)(H, 42, 43)
SMILES Code: O=C(O)CCCN1C(C)=C(CCCC(O)=O)C2=C1C(C#CC3=CC=C(OCCCCC4=CC=CC(F)=C4C)C=C3)=CC=C2F