BAN-ORL-24 HCl

InvivoChem Cat #:V4694CAS #:1401463-54-4 (HCl)Purity >=98%

Description: BAN ORL 24 is a novel, potent and selective NOP (nociceptin/orphanin FQ (N/OFQ) peptide receptor) receptor antagonist with IC50 values of 0.27, 2500, 6700 and > 10000 nM for NOP, kappa-, u- and delta-receptors respectively. NOP receptor mediates anti-analgesia induced by agonist-antagonist opioids. Compound 24 (BAN ORL 24) up to 1 microM did not modify the effects of classical opioid receptor agonists. Finally in vivo, in the mouse tail withdrawal assay, Compound 24 at 10 mg/kg antagonized the pronociceptive and antinociceptive effects of 1 nmol N/OFQ given supraspinally and spinally, respectively. Under the same experimental conditions Compound 24 did not affect the antinociceptive action of 3 nmol endomorphin-1 injected intrathecally. The present study demonstrated that Compound 24 is a pure, competitive, and highly potent non-peptide NOP receptor selective antagonist.

References: Eur J Pharmacol. 2009 Jul 1; 614(1-3):50-7.

-20C for 3 years in powder form

Synonym: BAN-ORL-24 HCl; BAN-ORL-24 dihydrochloride; BAN-ORL24; BAN-ORL 24; BANORL-24; BANORL 24; BANORL24; BAN ORL 24.
IUPAC/Chemical Name: (2R)-1-Benzyl-N-(3-spiro[isobenzofuran-1(3H), 4'-piperidin]-1'-ylpropyl)-2-pyrrolidinecarboxamide dihydrochloride.
InChi Key: NEEVITHVDIQNJY-KHZPMNTOSA-N
InChi Code: InChI=1S/C27H35N3O2.2ClH/c31-26(25-12-6-17-30(25)20-22-8-2-1-3-9-22)28-15-7-16-29-18-13-27(14-19-29)24-11-5-4-10-23(24)21-32-27; ; /h1-5, 8-11, 25H, 6-7, 12-21H2, (H, 28, 31); 2*1H/t25-; ; /m1../s1
SMILES Code: O=C([CH]1N(CC2=CC=CC=C2)CCC1)NCCCN3CCC4(CC3)OCC5=C4C=CC=C5.[H]Cl.[H]Cl