mtdia-hcl

InvivoChem Cat #:V4695CAS #:1399840-35-7 (HCl)Purity >=98%

Description: MTDIA (also known as MT-DADMe-ImmA and Methylthio-DADMe-Immucillin A) is a novel and potent inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP) with a Ki of 90 pM. Human 5'-methylthioadenosine phosphorylase (MTAP) is solely responsible for 5'-methylthioadenosine (MTA) metabolism to permit S-adenosylmethionine salvage. Transition-state (TS) analogues of MTAP are in development as anticancer candidates. TS analogues of MTAP incorporate a cationic nitrogen and a protonated 9-deazaadenine leaving group, which are mimics of the ribocation transition state. MT-ImmA and MT-DADMe-ImmA are two examples of these TS analogues.

References: J Med Chem. 2005 Jul 14; 48(14):4679-89.; J Biol Chem. 2007 Jul 20; 282(29):21477-86.

Related CAS : 1399840-35-7 (HCl); 653592-04-2 (free base)

-20C for 3 years in powder form

Synonym: Methylthio-DADMe-Immucillin A; MTDIA hydrochloride; MTDIA; MTDIA HCl; Methylthio-DADMe-Immucillin A; MT-DADMe-ImmA; MT-DADMe-ImmA HCl
IUPAC/Chemical Name: (3R, 4S)-1-((4-amino-5H-pyrrolo[3, 2-d]pyrimidin-7-yl)methyl)-3-hydroxy-4-((methylthio)methyl)pyrrolidin-1-ium chloride
InChi Key: XQKMBJFGNRIATG-UXQCFNEQSA-N
InChi Code: InChI=1S/C13H19N5OS.ClH/c1-20-6-9-4-18(5-10(9)19)3-8-2-15-12-11(8)16-7-17-13(12)14; /h2, 7, 9-10, 15, 19H, 3-6H2, 1H3, (H2, 14, 16, 17); 1H/t9-, 10+; /m1./s1
SMILES Code: NC(N=CN=C12)=C2NC=C1C[N+]3([H])C[CH]([CH](C3)O)CSC.[Cl-]