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BTK IN-1

BTK IN-1

Item no.	V4766-250mg
Manufacturer	InvivoChem LLC
CASRN	1270014-40-8
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4766CAS #:1270014-40-8Purity >=98% Description: BTK IN-1 (SNS-062 analog or Vecabrutinib analog) is a novel and potent BTK (Bruton's tyrosine kinase) inhibitor with an IC50 of< 100 nM. BTK IN-1 is a non-covalently/reversibly binding inhibitor of Bruton's tyrosine kinase. BTK IN-1 is an analog of vecabrutinib (formerly SNS-062; FP-182, BSK-4841 and BIIB-062) which is a novel, potent, and reversible/noncovalent BTK and ITK inhibitor with Kd of 0.3 nM and 2.2 nM, respectively; Vecabrutinib shows an IC50 of 24 nM for ITK. SNS-062 does not require interaction with BTK C481 for inhibitory activity. SNS-062 has improved PK properties over ibrutinib, including greater bioavailability and a longer half-life. SNS-062 may offer an alternative treatment option to patients with acquired resistance to ibrutinib. References: WO2011029043A1 CAS : 1270014-40-8 (SNS062 analog); 1510829-06-7 (SNS-062)
	CAS#: 1270014-40-8 Chemical Formula: C19H21ClN6O Exact Mass: 384.1465 Molecular Weight: 384.868 Elemental Analysis: C, 59.30; H, 5.50; Cl, 9.21; N, 21.84; O, 4.16
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: Vecabrutinib analog; BTK IN-1; BTK-IN-1; BTK IN 1; SNS-062 analog; SNS062 analog; SNS 062analog. IUPAC/Chemical Name: N-(1-(7H-pyrrolo[2, 3-d]pyrimidin-4-yl)piperidin-3-yl)-2-((3-chlorophenyl)amino)acetamide InChi Key: SPSNKQVUYDXOGY-UHFFFAOYSA-N InChi Code: InChI=1S/C19H21ClN6O/c20-13-3-1-4-14(9-13)22-10-17(27)25-15-5-2-8-26(11-15)19-16-6-7-21-18(16)23-12-24-19/h1, 3-4, 6-7, 9, 12, 15, 22H, 2, 5, 8, 10-11H2, (H, 25, 27)(H, 21, 23, 24) SMILES Code: O=C(CNC1=CC(Cl)=CC=C1)NC(CCC2)CN2C3=NC=NC4=C3C=CN4

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 250 mg

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Delivery expected until 11/6/2025

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