DT-061

InvivoChem Cat #:V4795CAS #:1809427-19-7Purity >=98%

Description: DT-061 (also known as SMAP) is a novel, potent and orally bioavailable activator of PP2A (protein phosphatase 2A). It could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis. Treatment with DT-061, in combination with the MEK inhibitor AZD6244, resulted in suppression of both p-AKT and MYC, as well as tumor regression in two KRAS-driven lung cancer mouse models. DT-061 therapy also abrogated MYC-driven tumorigenesis.

References: Sci Transl Med. 2018 Jul 18; 10(450). pii: eaaq1093.

Related CAS : 1809427-19-7; 1809427-18-6 (1S, 2S, 3R isomer)

-20C for 3 years in powder form

Synonym: SMAP; DT-061; DT061; DT 061; DT61; DT-61; DT 61
IUPAC/Chemical Name: N-((1R, 2R, 3S)-2-hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl)-4-(trifluoromethoxy)benzenesulfonamide
InChi Key: WGKGADVPRVLHHZ-ZHRMCQFGSA-N
InChi Code: InChI=1S/C25H23F3N2O5S/c26-25(27, 28)35-16-12-14-17(15-13-16)36(32, 33)29-18-6-5-9-21(24(18)31)30-19-7-1-3-10-22(19)34-23-11-4-2-8-20(23)30/h1-4, 7-8, 10-15, 18, 21, 24, 29, 31H, 5-6, 9H2/t18-, 21+, 24+/m1/s1
SMILES Code: O=S(C1=CC=C(OC(F)(F)F)C=C1)(N[CH]2[CH](O)[CH](N3C4=C(C=CC=C4)OC5=CC=CC=C35)CCC2)=O