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EXP-3174

EXP-3174

Item no.	V4802-10mg
Manufacturer	InvivoChem LLC
CASRN	151801-76-2
Amount	10 mg
Quantity options	100 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4802CAS #:151801-76-2Purity >=98% Description: EXP-3174 (also known as losartan aarboxylic acid), a physiologically active metabolite of losartan produced by cytochrome P450 isoforms in the liver, is a non-peptide, potent angiotensin II (AII) receptor, type 1 (AT1) antagonist, which inhibits the AII induced cellular responses. Like the parent compound losartan, EXP-3174 is a potent AT1 antagonist with Kis of 0.57 and 0.67 nM for rat and human forms, respectively. It produces a depressor response and vasodilatation. When administered intravenously, losartan carboxylic acid is more potent and has a longer duration of action than losartan. However, the metabolite has very low oral bioavailability. References: Clinical Science, 1996; 91(2): 147-154; Journal of Hypertension. 1993; 11(2): 155-162.
	Name: ZD 7155 hydrochloride CAS#: 151801-76-2 Chemical Formula: C26H27ClN6O Molecular Weight: 474.99 Elemental Analysis: C, 65.75; H, 5.73; Cl, 7.46; N, 17.69; O, 3.37
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: E-3174; E 3174; E3174; EXP-3174; EXP 3174; EXP3174; Losartan Carboxylic Acid. IUPAC/Chemical Name: 1-((2'-(1H-tetrazol-5-yl)-[1, 1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carboxylic acid InChi Key: ZEUXAIYYDDCIRX-UHFFFAOYSA-N InChi Code: InChI=1S/C22H21ClN6O2/c1-2-3-8-18-24-20(23)19(22(30)31)29(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21-25-27-28-26-21/h4-7, 9-12H, 2-3, 8, 13H2, 1H3, (H, 30, 31)(H, 25, 26, 27, 28) SMILES Code: [H]N1N=NN=C1C2=CC=CC=C2C3=CC=C(CN4C(C(O)=O)=C(Cl)N=C4CCCC)C=C3

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Amount: 10 mg

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