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Description: PD-1-IN-2898 (2989 is the last four digits of the CAS #), a 1, 2, 4triazolo4, 3- apyridine analog, is a novel and potent programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction inhibitor with an IC50 of 92.3 nM. Inhibition of the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction using small-molecule inhibitors is an emerging immunotherapeutic approach.
References: J Med Chem. 2019 May 9; 62(9):4703-4715.
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