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SAR-405

SAR-405

Item no.	V4833-100mg
Manufacturer	InvivoChem LLC
CASRN	1523406-39-4
Amount	100 mg
Quantity options	10 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4833CAS #:1523406-39-4Purity >=98% Description: SAR405 is a novel, potent and selective PIK3C3/Vps34 inhibitor with an IC50 of 1.2 nM. SAR405 prevents autophagy and synergizes with MTOR inhibition in tumor cells. SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition. Combining SAR405 with everolimus results in a significant synergy on the reduction of cell proliferation using renal tumor cells. References: Nat Chem Biol. 2014 Dec; 10(12):1013-9.; Autophagy. 2015 Apr 3; 11(4):725-6. Related CAS : 1523406-39-4; 1946010-79-2 (SAR405 R enantiomer)
	Name: SAR-405 CAS#: 1523406-39-4 Chemical Formula: C19H21ClF3N5O2 Exact Mass: 443.1336 Molecular Weight: 443.8552 Elemental Analysis: C, 51.42; H, 4.77; Cl, 7.99; F, 12.84; N, 15.78; O, 7.21
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: SAR-405; SAR 405; SAR405. IUPAC/Chemical Name: (S)-9-((5-chloropyridin-3-yl)methyl)-2-((R)-3-methylmorpholino)-8-(trifluoromethyl)-6, 7, 8, 9-tetrahydro-4H-pyrimido[1, 2-a]pyrimidin-4-one InChi Key: SPDQRCUBFSRAFI-DOMZBBRYSA-N InChi Code: InChI=1S/C19H21ClF3N5O2/c1-12-11-30-5-4-26(12)16-7-17(29)27-3-2-15(19(21, 22)23)28(18(27)25-16)10-13-6-14(20)9-24-8-13/h6-9, 12, 15H, 2-5, 10-11H2, 1H3/t12-, 15+/m1/s1 SMILES Code: O=C1C=C(N2[CH](C)COCC2)N=C3N(CC4=CC(Cl)=CN=C4)[CH](C(F)(F)F)CCN31

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Amount: 100 mg

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Delivery expected until 10/2/2025

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