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Gemcitabine elaidate

Gemcitabine elaidate

Item no.	V4887-50mg
Manufacturer	InvivoChem LLC
CASRN	210829-30-4
Amount	50 mg
Quantity options	100 mg 250 mg 25 mg 500 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4887CAS #:210829-30-4Purity >=98% Description: Gemcitabine elaidate (formerly know as CP-4126 and CO-101) is a potent, lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), which is an antimetabolite deoxynucleoside analogue with potential antineoplastic activity. Upon hydrolysis intracellularly by esterases, the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate (dFdCDP and dFdCTP) by deoxycytidine kinase. dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. Description: Gemcitabine elaidate (formerly know as CP-4126 and CO-101) is a potent, lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), which is an antimetabolite deoxynucleoside analogue with potential antineoplastic activity. Upon hydrolysis intracellularly by esterases, the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate (dFdCDP and dFdCTP) by deoxycytidine kinase. dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.Description References: J Clin Oncol. 2013 Dec 10; 31(35):4453-61. References: J Clin Oncol. 2013 Dec 10; 31(35):4453-61. References: J Clin Oncol. 2013 Dec 10; 31(35):4453-61. References CAS : 95058-81-4 (free base); 122111-03-9 (HCl); 116371-67-6 (Gemcitabine monophosphate free acid); 1638288-31-9 (Gemcitabine monophosphate disodium salt); 840506-29-8 Acelarin (NUC-1031) is a ProTide transformation and enhancement of the widely-used nucleoside analogue, gemcitabine; 892128-60-8 (LY2334737, an orally bioavailable prodrug of gemcitabine) CAS : 95058-81-4 (free base); 122111-03-9 (HCl); 116371-67-6 (Gemcitabine monophosphate free acid); 1638288-31-9 (Gemcitabine monophosphate disodium salt); 840506-29-8 Acelarin (NUC-1031) is a ProTide transformation and enhancement of the widely-used nucleoside analogue, gemcitabine; 892128-60-8 (LY2334737, an orally bioavailable prodrug of gemcitabine)CAS : 95058-81-4 (free base); 122111-03-9 (HCl); 116371-67-6 (Gemcitabine monophosphate free acid); 1638288-31-9 (Gemcitabine monophosphate disodium salt); 840506-29-8 Acelarin (NUC-1031) is a ProTide transformation and enhancement of the widely-used nucleoside analogue, gemcitabine; 892128-60-8 (LY2334737, an orally bioavailable prodrug of gemcitabine)
	Name: Gemcitabine elaidate CAS#: 210829-30-4 Chemical Formula: C27H43F2N3O5 Exact Mass: 527.31708 Molecular Weight: 527.644 Elemental Analysis: C, 61.46; H, 8.21; F, 7.20; N, 7.96; O, 15.16
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	8

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Amount: 50 mg

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Delivery expected until 10/2/2025

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