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Description: Eglumegad (also known as LY-354740) is a novel, highly potent and selective group II (mGlu2/3) receptor agonist with IC50s of 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively. Eglumegad is being investigated for its potential in the treatment of anxiety and drug addiction. It is a glutamate derived compound and its mode of action implies a novel mechanism.
References: Neurosci Lett. 2006 May 8; 398(3):328-32.; Eur J Neurosci. 2017 Apr; 45(7):912-921.
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