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Description: GW-791343 3HCl, the trihydrochloride salt form of GW-791343 (GW791343) is a novel, potent P2X7 allosteric modulator that exhibits species-specific activity and acts as a negative allosteric modulator of human P2X7 with pIC50 of 6.9 - 7.2. GW791343 is a positive allosteric modulator of rat P2X7.
References: Br J Pharmacol, 2009, 158(6), 1513-1526.; Br J Pharmacol, 2008, 155(5), 738-751.
Related CAS #: 309712-55-8 (3HCl); 1019779-04-4 (2HCl); 309712-73-0 (free base)
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