ym-254890

InvivoChem Cat #:V4938CAS #:568580-02-9Purity >=98%

Description: YM-254890, a cyclic depsipeptide discovered from Chromobacterium sp. QS3666 culture broth, is a novel, potent and specific galphaq/11 inhibitor. It can inhibit adp-induced platelet aggregation and blocking galphaq/11-coupled adp receptor p2y1-mediated ca2+ mobilization. YM-254890 concentration dependently inhibited ADP-induced intracellular Ca2+ elevation, with an IC50 value of 0.92+/-0.28?um. YM-254890 had no effect on the binding of fibrinogen to purified GPIIb/IIIa, but strongly inhibited binding to TRAP-stimulated washed platelets.

References: Br J Pharmacol. 2006 May; 148(1): 61–69.

Related CAS #: 568580-02-9 (YM-254890); 1702378-78-6 ( WU-07047, a simplified analog of the selective Galphaq/11 inhibitor YM-25489)

-20C for 3 years in powder form

Synonym: YM-254890; YM 254890; YM254890
Chemical Name: (R)-1-((3S, 6S, 9S, 12S, 18R, 21S, 22R)-21-Acetamido-18-benzyl-3-((R)-1-methoxyethyl)-4, 9, 10, 12, 16, 22-hexamethyl-15-methylene-2, 5, 8, 11, 14, 17, 20-heptaoxo-1, 19-dioxa-4, 7, 10, 13, 16-pentaazacyclodocosan-6-yl)-2-methylpropyl (2S, 3R)-2-acetamido-3-hydroxy-4-methylpentanoate
InChi Key: QVYLWCAYZGFGNF-WBWCVGBTSA-N
InChi Code: InChI=1S/C46H69N7O15/c1-22(2)37(56)34(49-30(11)55)45(63)68-38(23(3)4)35-43(61)53(14)36(28(9)65-15)46(64)66-27(8)33(48-29(10)54)44(62)67-32(21-31-19-17-16-18-20-31)42(60)52(13)25(6)39(57)47-24(5)41(59)51(12)26(7)40(58)50-35/h16-20, 22-24, 26-28, 32-38, 56H, 6, 21H2, 1-5, 7-15H3, (H, 47, 57)(H, 48, 54)(H, 49, 55)(H, 50, 58)/t24-, 26-, 27+, 28+, 32+, 33-, 34-, 35-, 36-, 37+, 38+/m0/s1
SMILES Code: CC(C)[CH](O)[CH](NC(C)=O)C(O[CH]([CH](NC([CH](C)N(C)C([CH](C)NC(C(N(C)C([CH](CC1=CC=CC=C1)O2)=O)=C)=O)=O)=O)C(N(C)[CH]([CH](OC)C)C(O[CH](C)[CH](NC(C)=O)C2=O)=O)=O)C(C)C)=O